Cellinsight, Aging, ageing- related diseases,

Cellinsight Everything about human ageing and related diseases Understanding The Metabolic Aging Theory Key points to remember Mitochondrial dysfunction,autophagy,caloric restrictions,carbohydrate metabolism, oxidative stress, nutrient sensing and metabolic flexibility .  The metabolic theory of aging presents a fascinating perceptive on the biological mechanisms underlying aging process, shedding light on intricate relationship between cellular metabolism and aging. This theory explores how energy production, mitochondrial dysfunction and metabolic rates influences our biological aging by delving into the impact of oxidative stress , mitochondrial dysfunction and the effect of caloric restriction on longevity.  Metabolism and Aging; key Concepts.  Mitochondrial dysfunction Mitochondrial dysfunction is the prime contributor of metabolic aging.Mitochondria play a vital role in energy production and storage, ofen referred to as the power house of our cells. The efficie...

Cellinsight Everything about human ageing and related diseases Understanding Wear And Tear Theory of Aging Aging is a natural process, as we age, our body deteriorate. The wear Tear theory explains how the accumulated cellular damage leads to physical damage over time. According to this theory cellular damage is the reason  behind Aging.  Key takeaways * This theory explains the role of DNA                   mutations, Impacts of free  -   radicals  and  protein   modifications * The theory  explains how the accumulated cellular damage leads to Aging * This theory helps to Identify the environmental factors that accelerate wear and tear, and how can one adopt preventive measures.  * This theory provide an insights into the basic biological mechanism related to age decline *  exploring the connection between Tear and Wear and Age related diseases.  Wear and Tear theory:Orgin and...

Genome Editing: A Comprehensive Guide Genome-editing Recently Genome editing has seen remarkable advancement in the field of medicine, agriculture and biotechnology. Genome editing started in 1990s.There are many Platforms available for genetical editing, they are ZFNs (zinc finger nucleases), TALENs (transcription activator-like effector nucleases), Meganucleases, CRISPR/ Cas systems etc. Cas systems is more efficient and convenient compared to other platforms.  1.CRISPR-Cas Systems.  CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas systems are famous for it's simplicity and efficiency, they are widely used for Gene-editing in recent years. When a bacterium infected by bacteriophage- virus, bacterial immune system, that's Crispr-Cas systems protect them. Crispr-Cas9 system found in streptococcus pyogenes , when virus attack this bacteria the Cas9- system detect it and bacteria produced a guide RNA ( gRNA ) that's complementary to viral DNA , i...

Cellinsight Everything about human ageing and related diseases An Introduction to Anti-Aging Supplements Anti-aging supplements Aging is natural,but many people maintain youthful vitality by consuming anti-aging supplements . Now a days these supplements are getting wide popularity, as people seak overall wellbeing and vitality. Demand for anti-anging supplements raising as global population ages. Today the anti-aging market projected to reach over 421 billion dollars.  Anti-Aging Supplements: Key ingredients.  1. resveratrol : Resveratrol  is a polyphenolic compound, it can be extracted from  grapes, cocoa, blueberries, cranberries,and many fruits and seeds. This compund is antioxidant, Anti-inflammatory,and neuro protective and cardio vascular protective. It also a regulator of glucose and lipids. It protect us from cardiovascular diseases, diabetes, cancer, alzheimer's etc. It is a best option for heart health and age-related diseases. It also activate c...