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Cross-linking theory of aging

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Structural changes of proteins due to molecular Cross-linking Cellinsight Everything about human ageing and related diseases Understanding Cross-linking theory The cross-linking theory of aging was proposed in 1942 by Johan Bjorksten. According to this theory Collagen and other proteins undergoing structural changes due to molecular cross linkage (collagen is an important body proteins comprising 30℅ of body proteins) . In the presence of oxygen glucose molecules binding to to proteins and this cross-linked proteins causing damage to cells and tissues resulting in aging. This theory is also called as glycosylation theory of aging.  # Wrinkle and skin changes The cross-linked skin protein collagen  is responsible for wrinkles and skin changes during aging # Tendon stiffening An increased cross-linked collagen is the reason behind tendon stiffening, tendons are connective tissues which connect muscles to bones. a stiff tendon can pass more mechanical energy from ...
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Neuro endocrine theory(biological clock) of aging

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NEURO ENDOCRINE THEORY OF AGING  According to Neuro endocrine theory the aging process is happening in hypothalamus,pituitary,and thyroid or the in regulatory action of these glands.Vladimer Dilman an internationally renowned endocrinologist put forward this theory in 1968.He found that there is considerable decline in the production of hormones in our body with increasing age,the secretion of thyroid,adrenel cortex,testis (males),ovary (females),pituitary (growth hormone) etc will falls.The production of aminoacids, peptides,monoamines enzymes etc also will decrease.it is also noted that the functional decline in neurons, Human endocrine system What are the functions of endocrine glands? Endocrine system is a group of glands,which produce most of all important hormones for our body.These hormones controls our growth development,moods,metabolism,reproduction etc. The glands includes Hypothalamus,pituitary,pineal(these3glands situated in brain),thyroid(ne...
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Lipids&ageing

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Cellinsight Everything about human ageing and related diseases Lipids Lipids are organic compounds, basically hydro carbons . They are non-polar ( means they don't have negatively or positively charged ends ) so they are not soluble in Water, but easily soluble in organic solvents such as chloroform, acetone, benzene,alcohol etc. Fats , oil , wax etc, are the examples of lipids . Lipids are necessary to make cell membranes, the outer most two layers of cell membrane is made up of phospholipids , which protect cell from surroundings and also helps cell more strong and flexible. Energy storage ( excess energy stored in adipose tissue in our body and used when ever needed ), they used to transmit nerve impulses, and many more..  Lipid metabolism Image credit goes to Commons.wikimedia.org           ( under common creative atribution)  Endocrine system in our body, releasing hormones which control growth and metabolism. According to the...
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