Cellinsight, Aging, ageing- related diseases,

Telomere theory of aging Telomere theory of aging was proposed by a Russian scientist A.M.Olovnikov in the year 1971.In the year 1961,an american scientist  L.Hayflick   discovered that cultured human cells can only divide up to 50 times.On the basis of this discovery and it's data A.M olovnikov studied more and proposed the telomere theory of aging . According to the theory,when the telomeres ( tail end of  chromosome ) become too short the cells lose their ability to divide,gradually it lose its efficiency and become aged.After each and every cell division  telomeres are unable to be fully copied,therefore they become shorter and shorter.The telomere theory was fully confirmed when an enzyme called telomerase was discovered in 1984, telomerase can maintain the length of telomeres in cancecells and germ cells ,these cells are devoid of aging and they are immortal.The telomere theory of aging got more popularity when three geneticists, Elis...

style="text-align: left;"> The free radical theory of aging Dr.Denham Herman a scientific researcher who proposed the ' free radical theory of aging ' in the year 1956.according to this theory the process of aging is due to oxidative damage of cell organelles and other cytoplasmic contents by free radicals. intially it was assumed that the free radicals such as ROS(reactive oxygen species) produced during normal respiratory process.The free radical theory got more attention when researchers studied the cause of cancer ,Alzheimer disease,and heart diseases .This theory realises that old age is just another disease,our old age is starting when mitochondrial DNA (mtDNA) get damaged by free radicals. 1970s many scientist involved in Reserch related to this theory and in 1980 J.Miquel clearly explained the mitochondrial involvement in the  production of free radicals,the theory is known as mitochondrial theory of free radicals. Cell struc...