DNA Damage Theory DNA damage by UV rays Image credit: Wikipedia The DNA Damage Theory helps to understand how long we live and our health. As we age genetically our cells become more and more damaged, this can be called as cellular aging The theory shows that Our DNA can hurt inany ways, from inside our bodies and from outside. Things like environmental factors and Oxidative stress can harm our DNA . Key takeaways • DNA can be damage by environmental exposures and oxidative stress. • The DNA damage theory explain how accumulated genetic damage contribute to cellular aging and impact overall health • Understanding the mechanism of DNA damage is necessary for developing intervention to extend lifespan. • Ongoing researches are focusing on DNA damage, cellular senescence, and age related diseases. • DNA repair and reduce the effect of DNA damage, may promote healthy aging. Understandin...
Why we are getting old? The answer is simple,the 'errors'.The errors that happening during cell multiplication and by the influences of external factors. So many changes happens in DNA every year,most important one is the shortening of telomeres. A telomere is the tail end of chromosomes. The free radical theory of -ageing, which devolved in1950 says that the reactive oxygen species(ROS) produced during mitochondrial functions react with their DNA (mtDNA) and other cell organelles, makes sever damage and declined mitochondrial functions that leads us to aging. ROS is produced when mitochondria make energy from food particles,when we eat more the mitochondria produce more energy and more ROS also evolved as by product. So having a comparatively limited amount of diet and anti oxidant rich food,such as green vegetables fruits etc can increase life span. Old age In the year 1961 an American scientist L.Hayflick disco...