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Human ageing

Understanding the DNA Damage Theory of Aging: Implications for Longevity and Health

DNA Damage Theory DNA damage by UV rays Image credit: Wikipedia The DNA Damage Theory helps to understand how long we live and our health. As we age genetically our cells become more and more damaged, this can be called as cellular aging The theory shows that  Our DNA can hurt inany ways, from inside our bodies and from outside. Things like environmental factors and Oxidative stress can harm our DNA .  Key takeaways • DNA can be damage by   environmental      exposures and oxidative  stress.  • The DNA damage theory explain how    accumulated genetic damage contribute to     cellular aging and impact overall health • Understanding the mechanism of DNA damage is necessary for developing intervention to extend lifespan.  • Ongoing researches are focusing on DNA damage, cellular senescence, and age related diseases.  • DNA repair and reduce the effect of DNA damage, may promote healthy aging. Understandin...
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Role of protein on ageing

Protein structure  Role of protein on aging  Protein which controls the length of telomere are telomerase and a protein complex known as shelterin.a new study by Scripps Reserch Institute (TSRI) discovered a new protein named as TZAP (telomeric zinc associated protein)which decrease the length of telomeres by trimming,telomere is the clock of a biological cell,if it's length is too short the cell cannot multiply,a human cell can divide maximum 50 times,if it increase more, our life span may increase considerably. Certain proteins undergo oxidisation which are known to be associated with ageing and some age related diseases,when people turn about 80 approximately half of the bady proteins are damaged due to oxidation,the oxidation occurs because of random chemical degradation,that are associated with convertion of food particles to energy ( metabolism) . Protein's mis foldings are another reason for ageing,when native proteins are synthesised in our cells,whic...
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What is protein?

What is protein? Protein is the basic components of living cells,it made of carbon,hydrogen,nitrogen and one or more chain of amino acids.Like carbohydrate and fats protein is a macro nutrient it is commonly available in animal products,eggs, meat, milk,yoghurt etc,it also available in beens, nuts,legumes etc.Proteins makeup 15 % of a person's body weight  According to their structure there are three types of proteins are there,they are fibrous, globular,and membrane.Fibrous proteins forms muscle  fibre, bones,connetive tissues and tendons,eg;actin,myosin,karatin.Globular protein is water soluble,they have so many functions in our body such as transporting,catalysing,and regulating ,eg; albumin,alphaglobin,hemoglobin etc.  According to their functions proteins are catagarised to eight groups,they are hormones, defensive proteins, enzymatic proteins,transport proteins,structural proteins,storage proteins,receptor proteins and contractile proteins. ...
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Why we are getting old?

  Why we are getting old? The answer is simple,the 'errors'.The errors that happening during cell multiplication and by the influences of external factors. So many  changes happens in DNA every year,most important one is the shortening of telomeres. A telomere is the tail end of chromosomes.  The free radical theory of -ageing,  which devolved in1950 says that  the reactive oxygen  species(ROS)   produced during mitochondrial functions react with their DNA (mtDNA)  and other cell organelles, makes sever damage and declined mitochondrial functions that leads us to aging. ROS is produced when mitochondria make energy from food particles,when we eat more the mitochondria produce more energy and more ROS also evolved as by product. So having a comparatively limited amount of diet and  anti oxidant rich food,such as green vegetables fruits etc can increase life span.  Old age In the year 1961 an American scientist  L.Hayflick  disco...
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